The film begins with a young boy, Thomas, taken in by Ava Paige (Patricia Clarkson) and troops from the organization WCKD, alongside other children, after being dropped off by his mother for his own safety. Years later, shortly after being rescued from the maze, Thomas (Dylan O’Brien) and the remaining Gladers – Newt (Thomas Brodie-Sangster), Minho (Ki Hong Lee), Teresa Agnes (Kaya Scodelario), Frypan (Dexter Darden) and Winston (Alexander Flores) – are taken to a facility run by Mr. Janson (Aidan Gillen). He explains that the facility is a safe haven, protecting them from WCKD, the Flare virus and the Cranks, and provides them clothes, food, and sanitation, where other survivors of multiple mazes are also present. Thomas becomes curious about their activities and manages to find out what is really happening behind the closed doors. With help from Aris Jones (Jacob Lofland), the first maze survivor to end up in the facility, it is revealed that WCKD’s leader, Ava, is still alive and that Mr. Janson is working for WCKD, as they discuss about the experiment on the Immunes and that Janson has yet to find The Right Arm, a resistance group located at the mountains. The group, including Aris, escapes the facility, as Janson orders his WCKD troops to track them down, where they find themselves in the deserted outside world – the Scorch. The group arrive at an abandoned marketplace, where they first encounter with the Cranks, humans zombified by the Flare virus. In the process, Winston gets infected by one of them. When morning comes, they find the city has turned into ruins and that WCKD is still searching for them. Winston’s infection gets worse, forcing the rest of the group to leave him alone to die by shooting himself, preventing his transformation. As group continues to venture the desert until one night, while sleeping in the middle of the desert, Thomas awakens and discovers civilization from far away. As a thunderstorm emerges, they run to an abandoned facility to keep them from the storm. Minho gets struck by the lightning, but he survives. They manage to enter the place, only to find out that the facility they entered was filled with chained Cranks. The group meets Brenda (Rosa Salazar) and Jorge (Giancarlo Esposito), who lead a dangerous band of survivors and have used the Cranks as their own guard dogs. When the two find that the group had come from WCKD and is looking for the Right Arm, the two agree to take them to the Right Arm, abandoning their group of survivors. Moments later, WCKD, led by Janson, storms the place, only for the facility to be destroyed by Jorge’s explosives, however, Thomas and Brenda are left behind as the rest have escaped with Jorge. Thomas and Brenda manage to escape the Cranks, only for Brenda to get infected by a Crank in the process. Thomas experiences a flashback of when he and Teresa were working for WCKD, in which Thomas tries to warn Teresa of WCKD’s plans, only for the two to be separated by WCKD’s troops. As Thomas and Brenda reunite with the rest of the group, Jorge interrogates Marcus (Alan Tudyk), a survivor who secretly works for WCKD, into revealing the whereabouts of The Right Arm. The group eventually arrive at The Right Arm’s relief camps, where other innocent survivors are present, and are greeted by Vince (Barry Pepper) who leads the Right Arm and is in charge of deciding whether they can stay or not. As Brenda’s infection gets worse, Vince threatens to shoot Brenda, only to be stopped by Mary Cooper (Lili Taylor), a former WCKD scientist who reveals that Thomas was their informant. As Mary halts Brenda’s infection using an enzyme cure, Mary explains that the enzyme can only be harvested from an Immune’s body, not manufactured, and that arguments over the methods of manufacturing the cure with Ava lead Mary’s departure from WCKD. That evening, Teresa calls WCKD of her location, believing that WCKD’s motivations are good, leading to an ambush by WCKD. Ava and Janson arrive and confront the Right Arm before WCKD troops captures survivors for experimentation, including Minho, while Janson shoots Mary dead. After Thomas and the Right Arm fend the WCKD troops off, Ava, Janson and Teresa retreat with their captured survivors. With only a fraction of survivors left at the site, Thomas plans an infiltration into WCKD and is determined to take them down to save his friends and save civilization, as his friends and the Right Arm agree to help and prepare to fight back.
某日，汤马士被送到了被称为“迷宮幽地”（Glade）的神秘之地，失去了除名字以外的记忆。他碰到了其他创造“迷宮幽地”的十几岁的男孩。創造者 明确地给每位居民分好工作，补给每周都会送来，每个月被称为“箱子”的电梯都会送来新男孩。到埠后不久，汤马士在最年长的领导者和其他人的引领下，游览了 林地。他还遇见了12岁的男孩纽特，纽特是林地的副官，与汤马士甚是亲近。后来，汤马士又碰到了令自己厌恶顿生的伽利，但又觉得他有点面熟。 林地被巨大的迷宫保卫著。机械生物鬼火獸夜间在其中出没。通往迷宫的大门在日落时分关闭，到了上午才重新打开。那里还有专门检测居民（幽地鬥士）行为的机械虫子“刀锋甲壳虫(甲蟲哨)”，它们的上面刻有“WICKED”字样。 探索迷宫的居民叫做“飛毛腿”。守护者中的飛毛腿民豪和艾尔比搜寻到一具鬼火獸的尸体，跟民豪前天在迷宫行走时发现的是同一类。颇让人惊讶的是，这 具尸体还活着，它蜇伤了艾尔比。民豪在纠缠中把阿尔比带回林地，但大门正要关闭，汤马士赶紧冲进迷宫里帮助，打破了任何人都不得进入迷宫的规则。 听到正在逼近的鬼火獸，民豪与汤马士和失去意识的艾尔比分开。湯马士用藤蔓把艾尔比拴住挂在墙上，救活了艾尔比，还找到了民豪，把追击的鬼火獸骗进 迷宫的深渊。用迷宮關閉時夾死鬼火獸。民豪和湯马士第二天早上在门打开时回到林地。身为代理领导的纽特用“聚会”决定未经允许进入迷宫的湯马士的命运。 不久后，一名昏迷中的女孩抵达时捎来了一张字条，上书“她是最后一个了。”后来她被带到医务室从昏迷中恢复过来，随机被问话。回到林地，汤马士被女 孩心灵感应的话语震惊了。她透露，自己叫特蕾莎，她说她已经引发了“结局”。此后不久，特蕾莎醒过来并跟汤马士结为好友。与此同时，汤马士得知居民们两年 来一直在努力解开迷宫，但屡遭失败，而用于悲情者的解药是被他们的记忆碎片蜇醒。汤马士在“地狱”监狱服务了一天后，成为飛毛腿。 後来，汤马士与民豪一同步入迷宫。他们很快透过悬崖发现了一个“悲情洞”，洞外别有洞天。他还发现了被藤蔓遮住的字：“灾难世界：杀戮地带实验部”，即缩写“WICKED”的全名。 同一天，天空转变成深灰色，托马斯认为是林地的缔造者在做过。当天晚上，迷宫的门并未像往常那样关上，居民们暴露在鬼火獸的眼前。每晚，鬼火獸都会 带走一个人，其中就有伽利。艾尔比烧掉了地图室，但民豪和其他飛毛腿把所有的地图转到了一间密室。居民们对准地图拼出彼此间没有关联单词，居民们确定这是 一个代码。 不顾一切寻找失去记忆的汤马士被鬼火獸蜇伤。恢复过来后，汤马士解释道，他和特蕾莎被迫帮助缔造者涉及迷宫。他表示自己跟特蕾莎可以共同作心灵感 应。看上去是迷宫出路的悬崖表面是一种欺骗了他们的错觉，它实际上是鬼火獸的进出口。他们跟随着鬼火獸在另一侧的电脑处输入代码，得以逃脱。汤马士带领居 民们进入迷宫，众人遭遇了一小波鬼火獸，一半的居民被杀，但汤马士、特蕾莎和查克跳入洞里，击中了代码而关闭了迷宫。附近出现了一扇门。 21名幸存的居民落入螺旋式的滑梯，来到了一处巨大的地下掩体。在那里，他们碰见了瘦削、脸色苍白、郁郁寡欢的缔造者们。他们都是成年人，做了大量 的记录在玻璃后面观察着居民们。一位女性向居民们打招呼，告诉他们干得不错。伽利出现了，他用刀把汤马士拽了过来，把刀扔向他。查克在刀的前面遁地了，牺 牲自己的性命去救他。被激怒的汤马士多次扼住盖伽利的喉咙，想让他窒息。 突然，一群枪手冲进房间，朝那名女性和缔造者开枪。居民们被推入一辆大型的巴士，离开这个建筑。他们上车时，一位伤痕累累的可怕女子拽住汤马士，告 诉他自己在被司机碾死前，是来把大家从耀斑中救出来的。汤马士和特蕾莎从救援者的口中得知，被太阳耀斑撞击的地球受到破坏，仅仅数天杀死了无数人，世界变 成荒芜之地。一种被称为“耀斑”的疾病正危及人类，而组织的目标是结束WICKED的测试，找到“耀斑（閃焰症）”的疗法。 数小时后，车子停在了一幢宿舍般的建筑中。在里头，居民们找到了带被子的双层床。他们终于感到安全。汤马士飘入了梦想，感到未来充满希望。 在尾声显而易见的是，被救出的居民们正接受迷宫缔造者的另一项测试，被救出的汤马士，绝不是唯一一个受到WICKED暗中观察的人物。