Captain Jack Sparrow finds the winds of ill-fortune blowing even more strongly when deadly ghost pirates led by his old nemesis, the terrifying Captain Salazar, escape from the Devil’s Triangle, determined to kill every pirate at sea…including him. Captain Jack’s only hope of survival lies in seeking out the legendary Trident of Poseidon, a powerful artifact that bestows upon its possessor total control over the seas.
故事发生在《加勒比海盗3：世界的尽头》沉船湾之战20年后。 男孩亨利（布兰顿•思怀兹 Brenton Thwaites 饰）随英国海军出航寻找被聚魂棺诅咒的父亲“深海阎王”威尔•特纳（奥兰多•布鲁姆 Orlando Bloom 饰），却在百慕大三角遭遇被解封的亡灵萨拉查船长（哈维尔•巴登 Javier Bardem 饰）。获取自由的萨拉查屠尽加勒比海盗，征服了整个海域，手刃了“黑胡子”爱德华•蒂奇（伊恩•麦柯肖恩 Ian McShane 饰）的里海海盗王赫克托•巴博萨船长（杰弗里•拉什 Geoffrey Rush 饰）在女巫Haifaa Meni(格什菲•法拉哈尼 Golshifteh Farahani 饰)口中得知了萨拉查的真实目的：为寻找他的宿敌杰克船长（约翰尼•德普 Johnny Depp 饰）。海盗的命运皆压在落魄的老杰克被封印的黑珍珠号，以及天文学家卡琳娜•史密斯（卡雅•斯考达里奥 Kaya Scodelario 饰）口中的远古三叉戟上。