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Extreme athlete turned government operative Xander Cage (Vin Diesel) comes out of self-imposed exile, thought to be long dead, and is set on a collision course with deadly alpha warrior Xiang (Donnie Yen) and his team in a race to recover a sinister and seemingly unstoppable weapon known as Pandora’s Box. Recruiting an all-new group of thrill-seeking cohorts, Xander finds himself enmeshed in a deadly conspiracy that points to collusion at the highest levels of world governments.
故事聚焦在由范·迪塞尔带头的的特工小队和以甄子丹为首的反派组织之间的对决。在这部作品中，迪塞尔饰演的特工凯奇不再是孤胆英雄，他将与一群出色的伙伴共同作战：塞缪尔·杰克逊饰演的国安局特工，印度女星迪皮卡·帕度柯妮饰演的与凯奇颇有渊源的女猎人，凭借《吸血鬼日记》走红的妮娜·杜波夫扮演的技术专家，《女子监狱》女星露比·罗丝饰演的狙击手,中国当红偶像演员吴亦凡饰演的特工Nicks。