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During Second Sino-Japanese War, China suffered from cholera outbreak because Japanese uses it as an biological weapon. Four Chinese agents captures a Japanese scientist and his bodyguard and interrogate them by Chinese opera in order to get the vaccine formula.
民国三十一年，“虎烈拉”横行华北。流氓（黄渤 饰）饿得不行，蹲在胡同里劫大户，没想到却把两个日本人劫到了一家日本料理店里。店里只有店主夫妇和一个驻店唱戏的戏子。中国店主夫妇，厨子（刘烨 饰）胆小如鼠，厨子老婆（梁静 饰）残疾弱智。戏子（张涵予 饰）颠三倒四，神神叨叨。三人陷入僵局，料理店外，此时日军和城中伪军正在进行全城地毯式搜查。之后事态发展却出人意料，闹剧迭出，情节爆笑百转。几人疯癫闹场的狂欢表象下，“曲线救国”的“愚人谍战”，才刚刚上演……