Bill Pope (Ryan Reynolds) is a CIA agent on a mission in London tracking down a shadowy hacker nicknamed “The Dutchman.” When he gets mysteriously ambushed and killed, an experimental procedure is used to transfer his memories into dangerous ex-convict Jericho Stewart (Kevin Costner). When he wakes up with the CIA agent’s memories, his mission is to find The Dutchman and eliminate him before the hacker launches ICBM’s and starts World War III. But complications soon arise and the mission turns personal.
一位知悉国家机密的CIA探员比利•波普（瑞恩•雷诺兹 Ryan Reynolds 饰）意外身亡，在弗兰克斯博士（汤米•李•琼斯 Tommy Lee Jones 饰）的协助下将其记忆与技能植入了一位极度危险且无法预测的罪犯杰里科•斯图尔特（凯文•科斯特纳 Kevin Costner 饰）身上，而探员贵格•威尔斯（加里•奥德曼 Gary Oldman 饰）必须靠这位不定时炸弹来摧毁企图攫取国家机密的犯罪组织。杰里科•斯图尔特为了救回换脑后渐渐爱上的比利•波普被胁迫的妻子和孩子，重新找回自己的生活，不得不在48小时的时间里，与犯罪组织展开殊死搏斗。