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Following an ace assassin who is double crossed by gangsters and falls into the hands of rogue surgeon known as The Doctor who turns him into a woman. The hitman now a hitwoman sets out for revenge, aided by a nurse named Johnnie who also has secrets.
影片讲述一名刺客遭到黑帮出卖，落入外科医生手中，结果变性成女人，刺客决议寻求黑帮和医生复仇的故事。罗德里格兹将分饰变性前后的刺客，韦弗则饰演那位变态医生。