Two Chinese merchant ships were attacked in Mekong river and 13 crews were killed. Thai policemen found 9 hundred thousand crystal meth on the ships. This new shocked China. Gang Gao, the leader of Narcotics Corps in Yun Nan province was assigned to lead a special team to Golden Triangle to investigate. Cooperated with a informer, Fanxin Wu, Gao discovered that 13 crew member were brutally murdered and framed up. Gao and Wu decided to fight for justice out of China no matter what it takes.
2011年10月5日，两艘中国商船在湄公河金三角水域遭遇袭击，13名中国船员全部遇难，泰国警方从船上搜出90万颗冰毒。消息传回国内，举国震惊。为了查明真相，云南缉毒总队长高刚（张涵予 饰）接受了特殊任务，率领一支骁勇善战的战斗小组进入泰国境内，与潜伏在泰国的情报员方新武（彭于晏 饰）碰头，二人联手深入金三角查案。经过调查，发现案件背后果然有着重重疑点，真正的凶手在嫁祸残害无辜中国船员后，不但逍遥法外，更意图利用毒品制造更大的阴谋……二人决定，不惜一切代价也要拿下真凶，打击毒品犯罪，为无辜国人讨回公道！