In Orlando, Florida, Quentin “Q” Jacobsen lives next door to Margo Roth Spiegelman, his childhood friend from whom he has since drifted, but still has feelings for. One night, when she climbs through his window and summons him on an all-night road trip of revenge, he cannot help but follow her lead. The next day, however, Margo does not come to school, and after a few days some consider her missing, others just conclude she left to an undisclosed location. Q soon learns that Margo left clues about where she would be going, and concludes she is in a particular paper town in New York state. Q goes there by car with his best friends Ben and Radar, Radar’s girlfriend Angela, and one of Margo’s best friends, Lacey. They are in a hurry, because they want to be back in time for the prom. On the way Ben gets very happy about the fact that afterwards Lacey will go to the prom with him. Margo does not show up at the assumed spot. Q stays, while the others return with the car. He finds her, but she is not in love with him. She left the clues just to let him know she is safe, not to invite him to follow her. Q returns by bus and Margo stays.
昆汀從小就一直單戀勇於冒險的隔壁鄰居——瑪歌，但兩人在學校裡的生活卻是天差地遠。某天晚上，瑪歌打開昆汀房間的窗戶重新踏入他的生命，並要求他協助一連串的報復行動，而昆汀也乖乖答應。 在通宵的冒險結束後，翌日，昆汀像往常一樣來到學校時卻發現瑪歌離奇地失蹤。她的家人與警察都認爲她不過是又開了一個小玩笑，昆汀卻覺察出其中的異樣。根據瑪歌昨晚的反常舉動與她刻意留下的蛛絲馬跡，昆汀與他的朋友開始了尋找瑪歌的旅程。