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Following Jigsaw’s grisly demise, Mark Hoffman, the final apprentice to the serial killer is deigned a hero. Meanwhile, Agent Strahm continues to track Hoffman while another group of strangers are put through a series of gruesome traps.
当游戏进行到第五集，霍夫曼（柯达斯曼迪洛饰演）接替了拼图杀人魔的位置开始了他无止尽的谋杀行动。当他发现自己的凶残行为似乎快要被揭穿时，他利用他之前当警探的技能追踪并且销毁所有可能会让他凶行曝光的所有人、事、物。