A psychic doctor, John Clancy (Anthony Hopkins), works with an FBI special agent (Jeffrey Dean Morgan) in search of serial killer Charles Ambrose (Colin Farrell).[5] After having lived in isolation for two years, since the death of his daughter, Clancy is asked by his friend Joe, an FBI special agent to help him solve several murders committed by a serial killer. The problem is that Ambrose is also psychic, and far ahead of Clancy.
一系列手法怪异且毫无动机的连环杀人案让FBI特别行动组特工乔（杰弗里•迪恩•摩根 饰）和女搭档凯瑟琳（艾比•考尼什 饰）一筹莫展。迫于无奈，他们只得邀请隐居的通灵神探约翰（安东尼•霍普金斯 饰）重出江湖。在追查线索的过程中，约翰赖以成名的读取过去、感知未来的通灵能力接连遭到挑战。藏在暗处的连环杀手（科林•法瑞尔 饰）好似开了天眼，不仅再度行凶，甚至在犯罪现场留下纸条，写明警方的到达时间进行挑衅。 随着案情逐渐明朗，约翰才意识到，原来这个连环杀手有着比自己更强的通灵能力，之前追查案情时所找到的“线索”，全是杀手故意留下的！就在这场灵能对决即将陷入完败之时，连环杀手却主动现身，将杀人动机与约翰痛苦的过去联系在一起。横祸已至，通灵神探该如何面临这场行至绝境的通灵对决……