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Sok-woo and his daughter Soo-ahn are boarding the KTX, a fast train that shall bring them from Seoul to Busan. But during their journey, the train is overrun by zombies which kill several of the train staff and other passengers.While the KTX is shooting towards Busan, the passengers have to fight for their lives against the zombies.
生化危機屍虐全韓，這班列車，是活命的最後希望！事業有成的證券經理人碩宇（孔劉 飾演）耽於金融遊戲導致離婚，也疏於照顧女兒秀安，讓備感寂寞的秀安滿心只想去釜山找媽媽，碩宇不得已才帶女兒搭上從首爾往釜山的高鐵。這趟乍看單純的旅程，卻成為逃離地獄的最後機會！來源不明的病變殭屍肆虐首爾，韓國面臨亡國滅種的危機！碩宇才送女兒上車，食人殭屍就侵襲了車站，沒有受到病毒感染的人們，紛紛想擠上這班最終生存列車，但是成功擠上車的，不是只有活人……從首爾到釜山的442公里，在極速飛馳的高速鐵路之上，絕望的人們是否能夠重拾希望，曾經迷失的單親爸爸碩宇是否能夠找到心的方向，守護愛女活命抵達安全的地方？