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Flight 7500 departs Los Angeles International Airport bound for Tokyo. As the overnight flight makes its way over the Pacific Ocean during its ten-hour course, the passengers encounter what appears to be a supernatural force in the cabin.
《7500航班》是继2006年的《美国版咒怨2》后，清水崇执导的第三部好莱坞影片。7500航班飞机上的一名乘客离奇死亡，一系列超自然的灵异惊悚现象随之而来，乘客们胆战心惊，均害怕下一个被害的人会是自己。