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Pandemic is set in the near future, where a virus of epic proportions has overtaken the planet. There are more infected than uninfected, and humanity is losing its grip on survival. Its only hope is finding a cure and keeping the infected contained. Lauren (Rachel Nichols) is a doctor, who, after the fall of New York, comes to Los Angeles to lead a team to hunt for and rescue uninfected survivors.
近未来，神秘的菲拉病毒肆意蔓延，感染者免疫力下降，经历几个发病阶段后会变得极为疯狂。他们会攻击其他人，而被感染者也很快会转化为丧失人性的攻击者，国际大都会纽约就此沦陷。这一日，前医生劳伦•蔡斯（瑞秋•尼科尔斯 Rachel Nichols 饰）受命前往一个补给站去取回89个菲拉病毒的血样，并寻找幸存者。这次征程凶险非常，稍不留神就会死于非命。小分队刚刚驶出隔离区，就遭到大批感染者的袭击。经过血腥的对抗，他们总算完好无缺冲出重围。 然而这一路险象环生，并且计划发生了变更，谁也不知道自己的命运将会如何……